Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2020
Hypolipidemic and anti-inflammatory properties of phenolic rich Butia odorata fruit extract: potential involvement of paraoxonase activity.
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Ramos Vanessa Plasse, da Silva Pamela Gonçalves, Oliveira Pathise Souto, Bona Natália Pontes, Soares Mayara Sandrielly Pereira, Cardoso Juliane de Souza, Hoffmann Jessica Fernanda, Chaves Fábio Clasen, Schneider Augusto, Spanevello Roselia Maria, Lencina Claiton Leoneti, Stefanello Francieli Moro, Tavares Rejane Giacomelli
Аннотация
Aim: This study investigated the effects of polar Butia odorata fruit extract on metabolic, inflammatory, and oxidative stress parameters in rats submitted to a hyperlipidaemia condition induced by tyloxapol.Methods: Animals were divided into 3 groups: saline, saline plus tyloxapol, and B. odorata extract plus tyloxapol. Animals were treated for 15 days with a saline solution or B. odorata fruit extract and after hyperlipidaemia was induced by tyloxapol.Results: Treatment with B. odorata extract reduced serum triglyceride, total cholesterol, C-reactive protein, and adenosine deaminase and butyrylcholinesterase activities when compared to the tyloxapol group. HDL-cholesterol and paraoxonase 1 activity were higher in B. odorata extract treated animals when compared to tyloxapol-treated animals. No differences were observed in hepatic oxidative stress parameters. Phenolic compounds present in B. odorata fruit extract were identified and quantified by LC-MS/MS.Conclusion: These findings indicated that phenolic rich B. odorata extract has hypolipidemic and anti-inflammatory effects in hyperlipidemic rats.