Medicina · 2025
[Regional and sex variations in mortality from chronic kidney disease in Argentina (2017-2019)].
Аннотация на английскомСтатьяНазвание и аннотация: Перевод в очереди
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Aparicio María Lourdes, Canale Marcela, Carrillo Mariana N, Diaz María Del Pilar, Butinof Mariana
Аннотация
INTRODUCTION: Chronic kidney disease (CKD) represents a growing health burden, with insufficient epidemiological evidence. The objective was to characterize the spatial distribution of CKD mortality in Argentina by sex, age group, and regions.
MATERIALS AND METHODS: Crude mortality rates (CMR), age-standardized mortality rates (ASMR), and age-specific mortality rates for CKD (ICD-10: N18) were calculated per 100 000 inhabitants for Argentina's 511 departments, grouped by geographic regions and stratified by sex; period 2017-2019. Mortality rates (MR) were represented in choropleth maps at the departmental level. Rates were compared by sex, and regional effects were evaluated by fitting a generalized Poisson regression model. Spatial autocorrelation was assessed using Moran's global index. A ratio between departmental ASMR and the national average was calculated, categorizing departments by percentiles (=P25, P25-average, average-P90, =P90), sex, and total population.
RESULTS: A total of 10 850 CKD deaths were registered in Argentina (54% among males), with CMR and ASMR of 8.4 (95% CI: 7.8-9.1) and 9.2 (95% CI: 8.5-10.0) per 100 000 inhabitants, respectively. At the regional level, significantly different patterns were observed, with higher MR in males and a marked increase in mortality after the age of 60. Mortality rates showed spatial autocorrelation, with high mortality burdens in the northwest and southern regions of the country.
DISCUSSION: Spatial clustering patterns in CKD mortality were identified in Argentina. The findings highlight the need for health policies that integrate sex- and region-specific approaches to reduce the burden of this disease with equity-based criteria.
MATERIALS AND METHODS: Crude mortality rates (CMR), age-standardized mortality rates (ASMR), and age-specific mortality rates for CKD (ICD-10: N18) were calculated per 100 000 inhabitants for Argentina's 511 departments, grouped by geographic regions and stratified by sex; period 2017-2019. Mortality rates (MR) were represented in choropleth maps at the departmental level. Rates were compared by sex, and regional effects were evaluated by fitting a generalized Poisson regression model. Spatial autocorrelation was assessed using Moran's global index. A ratio between departmental ASMR and the national average was calculated, categorizing departments by percentiles (=P25, P25-average, average-P90, =P90), sex, and total population.
RESULTS: A total of 10 850 CKD deaths were registered in Argentina (54% among males), with CMR and ASMR of 8.4 (95% CI: 7.8-9.1) and 9.2 (95% CI: 8.5-10.0) per 100 000 inhabitants, respectively. At the regional level, significantly different patterns were observed, with higher MR in males and a marked increase in mortality after the age of 60. Mortality rates showed spatial autocorrelation, with high mortality burdens in the northwest and southern regions of the country.
DISCUSSION: Spatial clustering patterns in CKD mortality were identified in Argentina. The findings highlight the need for health policies that integrate sex- and region-specific approaches to reduce the burden of this disease with equity-based criteria.