Genetics in medicine : official journal of the American College of Medical Genetics · 2002
Prevalence of aortic root dilation in the Ehlers-Danlos syndrome.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Wenstrup Richard J, Meyer Richard A, Lyle Jennifer S, Hoechstetter Leah, Rose Peter S, Levy Howard P, Francomano Claire A
Аннотация
PURPOSE: To determine the prevalence of proximal aortic abnormalities in patients with Ehlers-Danlos syndrome (EDS).
METHODS: In a prospective cohort study, aortic measurements by two-dimensional echocardiography were performed on consecutive EDS patients.
RESULTS: Twenty-eight percent (20 of 71) had aortic root dilation (ARD) (> +2 SD above population based norms). Fourteen of 42 individuals with the classical form of EDS (types I/II) and 6 of 29 individuals with the hypermobile form (type III) had ARD, with no gender differences.
CONCLUSION: ARD is a common finding in EDS. Longitudinal studies are indicated to determine progression of ARD and its clinical significance.
METHODS: In a prospective cohort study, aortic measurements by two-dimensional echocardiography were performed on consecutive EDS patients.
RESULTS: Twenty-eight percent (20 of 71) had aortic root dilation (ARD) (> +2 SD above population based norms). Fourteen of 42 individuals with the classical form of EDS (types I/II) and 6 of 29 individuals with the hypermobile form (type III) had ARD, with no gender differences.
CONCLUSION: ARD is a common finding in EDS. Longitudinal studies are indicated to determine progression of ARD and its clinical significance.