Using brain structural neuroimaging measures to predict psychosis onset for individuals at clinical high-risk.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zhu Yinghan, Maikusa Norihide, Radua Joaquim, Sämann Philipp G, Fusar-Poli Paolo, Agartz Ingrid, Andreassen Ole A, Bachman Peter, Baeza Inmaculada, Chen Xiaogang, Choi Sunah, Corcoran Cheryl M, Ebdrup Bjørn H, Fortea Adriana, Garani Ranjini Rg, Glenthøj Birte Yding, Glenthøj Louise Birkedal, Haas Shalaila S, Hamilton Holly K, Hayes Rebecca A, He Ying, Heekeren Karsten, Kasai Kiyoto, Katagiri Naoyuki, Kim Minah, Kristensen Tina D, Kwon Jun Soo, Lawrie Stephen M, Lebedeva Irina, Lee Jimmy, Loewy Rachel L, Mathalon Daniel H, McGuire Philip, Mizrahi Romina, Mizuno Masafumi, Møller Paul, Nemoto Takahiro, Nordholm Dorte, Omelchenko Maria A, Raghava Jayachandra M, Røssberg Jan I, Rössler Wulf, Salisbury Dean F, Sasabayashi Daiki, Smigielski Lukasz, Sugranyes Gisela, Takahashi Tsutomu, Tamnes Christian K, Tang Jinsong, Theodoridou Anastasia, Tomyshev Alexander S, Uhlhaas Peter J, Værnes Tor G, van Amelsvoort Therese A M J, Waltz James A, Westlye Lars T, Zhou Juan H, Thompson Paul M, Hernaus Dennis, Jalbrzikowski Maria, Koike Shinsuke, ENIGMA Clinical High Risk for Psychosis Working Group
Аннотация
Machine learning approaches using structural magnetic resonance imaging (sMRI) can be informative for disease classification, although their ability to predict psychosis is largely unknown. We created a model with individuals at CHR who developed psychosis later (CHR-PS+) from healthy controls (HCs) that can differentiate each other. We also evaluated whether we could distinguish CHR-PS+ individuals from those who did not develop psychosis later (CHR-PS-) and those with uncertain follow-up status (CHR-UNK). T1-weighted structural brain MRI scans from 1165 individuals at CHR (CHR-PS+, n = 144; CHR-PS-, n = 793; and CHR-UNK, n = 228), and 1029 HCs, were obtained from 21 sites. We used ComBat to harmonize measures of subcortical volume, cortical thickness and surface area data and corrected for non-linear effects of age and sex using a general additive model. CHR-PS+ (n = 120) and HC (n = 799) data from 20 sites served as a training dataset, which we used to build a classifier. The remaining samples were used external validation datasets to evaluate classifier performance (test, independent confirmatory, and independent group [CHR-PS- and CHR-UNK] datasets). The accuracy of the classifier on the training and independent confirmatory datasets was 85% and 73% respectively. Regional cortical surface area measures-including those from the right superior frontal, right superior temporal, and bilateral insular cortices strongly contributed to classifying CHR-PS+ from HC. CHR-PS- and CHR-UNK individuals were more likely to be classified as HC compared to CHR-PS+ (classification rate to HC: CHR-PS+, 30%; CHR-PS-, 73%; CHR-UNK, 80%). We used multisite sMRI to train a classifier to predict psychosis onset in CHR individuals, and it showed promise predicting CHR-PS+ in an independent sample. The results suggest that when considering adolescent brain development, baseline MRI scans for CHR individuals may be helpful to identify their prognosis. Future prospective studies are required about whether the classifier could be actually helpful in the clinical settings.