Percutaneous Hepatic Perfusion: Continuum of Nursing Care and Safety Implications for Managing Patients With Metastatic Uveal Melanoma.

BACKGROUND

Uveal melanoma is a rare cancer that can metastasize to the liver. Percutaneous hepatic perfusion (PHP) is a minimally invasive technique that delivers melphalan directly to the liver to treat metastatic uveal melanoma.

OBJECTIVES

This article presents nursing care and safety recommendations across all phases of the PHP procedure for patients with metastatic uveal melanoma.

METHODS

A multidisciplinary team of subject matter expert nurses, along with a clinic-based physician assistant, reviewed current literature, clinical guidelines, and trial protocols. The team identified best practices for nursing care during clinic visits, preprocedure preparation, intraprocedure monitoring, hazardous drug safe handling, postprocedure care, critical care and recovery, and follow-up.

FINDINGS: Collaborative nursing care across specialties is essential for the safe and effective delivery of melphalan via PHP. These recommendations provide guidance on patient assessment, monitoring, management of adverse events, and patient education. As PHP becomes more widely used nationally, nurses unfamiliar with this specialized procedure will benefit from structured, evidence-informed care protocols.