Computational Modeling and Simulation to Quantify the Effects of Obstructions on the Performance of Ventricular Catheters Used in Hydrocephalus Treatment.

Pediatric hydrocephalus is a debilitating condition that affects an estimated 1-2 in 1000 newborns, and there is no cure. A traditional treatment is surgical insertion of a shunt system which was designed 50 years ago, and minimal ensuing progress has been made in improving the failure rate of these devices resulting in the need for multiple brain surgeries during an affected child's lifetime for shunt replacement. A first step toward decreasing the failure rate is to optimize the ventricular catheter component of the shunt to minimize its propensity for obstruction. Given the many geometric properties and patient specific in vivo conditions needed to characterize the fluid dynamics affecting ventricular catheter performance, validated computational simulation is an efficient method to rapidly explore and evaluate the effects of this large parameter space to inform improved design and to investigate patient specific shunt performance. This chapter provides the details on how to build a computational model of a ventricle and implanted catheter, analyze the fluid dynamics through an obstructed catheter, and postprocess the results to predict catheter performance for varying geometry and in vivo conditions.