Does persistent active trachoma mandate antibiotic mass drug administration? A comparison of prevalence of trachomatous inflammation-follicular with that of conjunctival infection and anti-chlamydial antibodies, Western Province, Zambia.
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Ошибки и ограничения
История · было → стало
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Mwale Consity, Mboni Chileshe, Saasa Ngonda, Sikasunge Chummy S, Chelu Chisanga, Moonga Phyllis M, Hameja Grace, Nkhoma Levison, Shamilimo Frank, Kunda Namasiku S, Mulenga Glenda, Naluonde Tabonga, Mutale Nicholas, Boyd Sarah, Pearson-Clarke Rosemary, Bakhtiari Ana, Jimenez Cristina, Harding-Esch Emma M, Dejene Michael, Gass Katherine, Farber Katrina, Bah Mohamed, Mpyet Caleb, Masaninga Freddie, Bakyaita Nathan Nsubuga, Lundamo Mwila, Mutati Grace Chipalo, Mubita Sikufele, Kwendakwema Davison J, Courtright Paul, Solomon Anthony W, Muma Kangwa I M
Аннотация
METHODS: We conducted a cluster-sampled cross-sectional survey. In selected households, we examined all consenting residents ≥1 y of age for trachoma. We collected dried blood spots (DBSs) by finger-prick from children ages 1-9-y and conjunctival swabs from the left eyes of children ages 1-5-y. DBSs were tested for antibodies to the C. trachomatis antigen Pgp3 by lateral flow assay. We tested conjunctival swabs for C. trachomatis DNA by GeneXpert polymerase chain reaction (PCR).
RESULTS: The TF prevalence in children ages 1-9-y was 9.2%. In children ages 1-5-y, anti-Pgp3 seroprevalence was 1.7% and the seroconversion rate was 0.6 per 100 person-years. The prevalence of conjunctival C. trachomatis DNA in children ages 1-5-y was 0%.
CONCLUSIONS: Based on TF prevalence, this population qualified for additional antibiotic mass drug administration rounds, but PCR and serology-more specific indicators of current or recent C. trachomatis infection than TF-confirmed an absence of significant current community C. trachomatis transmission, allowing a transition to surveillance. Adding these indicators is helpful in persistent active trachoma.