Phytomedicine : international journal of phytotherapy and phytopharmacology · 2018
Potential therapeutic effect of curcumin, a natural mTOR inhibitor, in tuberous sclerosis complex.
СтатьяНазвание и аннотация: Перевод в очереди
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Kuo Chu-Jen, Huang Chi-Chen, Chou Szu-Yi, Lo Yu-Chun, Kao Tzu-Jen, Huang Nai-Kuei, Lin Connie, Lin Hsin-Chuan, Lin Hui-Ching, Lee Yi-Chao
Аннотация
BACKGROUND: Curcumin is a polyphenol natural product of the plant Curcuma longa. Recent studies suggest that curcumin inhibit mTOR activity in vitro, which prompts us to investigate curcumin function as a new class of mTOR inhibitor suitable for tuberous sclerosis complex (TSC) treatment.
PURPOSE: We aim to investigate the efficacy of curcumin in the treatment of TSC related manifestations in animal model.
STUDY DESIGN: Solid lipid curcumin particle (SLCP), a novel curcumin formulation, was used to treat TSC related manifestations in Tsc2 knockout mice.
METHODS: The novel object recognition test was used to analyze the recognition memory function. The long-term potentiation was studied using electrophysiological analysis. Western blotting was used to assess the protein expression and activation status.
RESULTS: Recognition memory deficit began as early as 4 weeks of age in both male and female Tsc2+/- mice. Oral administration with SLCP activates AMPK activity and inhibits mTOR activity in the brain tissue of Tsc2+/- mice, and can rescue the electrophysiological abnormality and object recognition memory loss in the mice.
CONCLUSIONS: Our results suggest that SLCP could be an effective treatment for TSC patients.
PURPOSE: We aim to investigate the efficacy of curcumin in the treatment of TSC related manifestations in animal model.
STUDY DESIGN: Solid lipid curcumin particle (SLCP), a novel curcumin formulation, was used to treat TSC related manifestations in Tsc2 knockout mice.
METHODS: The novel object recognition test was used to analyze the recognition memory function. The long-term potentiation was studied using electrophysiological analysis. Western blotting was used to assess the protein expression and activation status.
RESULTS: Recognition memory deficit began as early as 4 weeks of age in both male and female Tsc2+/- mice. Oral administration with SLCP activates AMPK activity and inhibits mTOR activity in the brain tissue of Tsc2+/- mice, and can rescue the electrophysiological abnormality and object recognition memory loss in the mice.
CONCLUSIONS: Our results suggest that SLCP could be an effective treatment for TSC patients.