Медицинская библиотека · Ophthalmic genetics · 2016

The TNF-α-308G/A Polymorphism is Not Associated with Ocular Chlamydia trachomatis Infection in Han Chinese Children.

Xue Wenwen, Wang Qingzhong, Li Zhiqiang, Lu Lina, Zhu Jianfeng, He Xiangui, Zhao Rong, Shi Yongyong, Zou Haidong

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Аннотация

OBJECTIVE

To investigate the association between the TNF-α-308G/A polymorphism and ocular chlamydia trachomatis (C. Trachomatis) infection among Han Chinese children.

METHODS

248 patients and 162 matched healthy controls were recruited. The diagnosis of ocular C. Trachomatis infection was given after clinical observation and latex immunochromatography tests. The TNF-α-308G/A polymorphism was genotyped by sequencing.

RESULTS

No association was found between the TNF-α-308G/A polymorphism and ocular C. Trachomatis infection.

CONCLUSIONS

The TNF-α-308A polymorphism is unlikely to play a major role in the risk for ocular C. Trachomatis in the Chinese population.

Для цитирования: Xue Wenwen, Wang Qingzhong, Li Zhiqiang, Lu Lina, Zhu Jianfeng, He Xiangui, Zhao Rong, Shi Yongyong, Zou Haidong. The TNF-α-308G/A Polymorphism is Not Associated with Ocular Chlamydia trachomatis Infection in Han Chinese Children.. Ophthalmic genetics. 2016. DOI: 10.3109/13816810.2015.1028650.

Предметные рубрики MeSH

Asian People Child China Chlamydia trachomatis Eye Infections, Bacterial Female Gene Frequency Genotyping Techniques Humans Male Polymorphism, Single Nucleotide Trachoma Tumor Necrosis Factor-alpha

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