Effects of naringenin on allodynia and hyperalgesia in rats with chronic constriction injury-induced neuropathic pain.

OBJECTIVE

To study the analgesic effects of naringenin on chronic constriction injury (CCI) model of neuropathic pain.

METHODS

After inducing of neuropathic pain by CCI, treatment with 25 and 50 mg/kg of naringenin and 10 mg/kg of pregabalin was given. Rats were evaluated for behavioral tests using Hargreaves apparatus for thermal hyperalgesia, pin prick test for tactile mechanical hyperalgesia and cold water-induced allodynia on days 0, 3, 5, 7, 14 and 21. At the end of study, oxidative stress parameters were measured.

RESULTS

Naringenin showed ameliorating action against CCI-induced neuropathic pain in all the tested models. Also, naringenin attenuated the elevated levels of lipid peroxidation and nitric oxide, and restored the level of reduced glutathione.

CONCLUSION

The results of the present investigation suggest that naringenin exhibits analgesic effect in sciatic nerve injury model.