Hypercholesterolemia as the first manifestation of metabolic abnormalities in normoglycemic young adult male with family history of type 2 diabetes mellitus.

BACKGROUND

Although several studies reported high number of metabolic disorder among First Degree Relatives (FDR) of Type 2 Diabetes Mellitus (T2DM), only a few studies analyzed the impact of gender on the occurence of metabolic abnormalities.

AIMS: This study aimed to investigate the first manifestation of metabolic abnormalities in normoglycemic FDR of T2DM.

METHODS AND MATERIALS: This cross-sectional study recruited 60 FDR of T2DM age of 19-39 years old in Jakarta, Indonesia. We matched 60 non-FDR as controls. All participants had neither glucose intolerance nor hypertension. Anthropometry, body composition and laboratory measurements (blood glucose, HbA1c, lipid profile, liver and kidney function test) were assessed.

RESULTS

In males, FDR aged 30-39 years old had higher Total Cholesterol (TC) level ([233 ± 51.43 mg/dL vs. 177.83 ± 22.08 mg/dL, p = 0.036] and Low Density Lipoprotein Cholesterol (LDL-C) level [173.83 ± 39.83 mg/dL vs. 125.67 ± 21.50 mg/dL, p = 0.026] than those of non-FDR significantly. FDR also had higher risk of hypercholesterolemia than non-FDR [OR 5.25 (1.09-25.21)]. There were no differences of metabolic abnormalities between female FDR and non-FDR group.

CONCLUSION

Male FDR of T2DM showed higher level of TC and LDL-C level than those of non FDR. Male FDR also showed higher risk of dyslipidemia.