Journal of chromatographic science · 2021
Simultaneous Determination of Nitrite and Azide Ions in Valsartan.
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Liu Xueyun, Hu Tianjiao
Аннотация
OBJECTIVE: This study aimed to establish an ion chromatography for the simultaneous determination of nitrite and azide ions in valsartan.
METHODS: Dionex IonpacAG18 (4 × 50 mm2) and Dionex IonpacAS18 (4 × 250 mm2) were used as the 2D guard column and analytical column, respectively. Dionex AMGTMC18 (4 × 30 mm2) was used as a 1D pre-separation column and Dionex UTAC-ULP1 as the concentration column. KOH solution generated by an online eluent generator (EG) was used as the 2D mobile phase, and gradient elution was performed at 1 mL/min. Water and acetonitrile were used as 1D mobile phase, and gradient elution was performed at 0.5 mL/min. Suppressed conductivity detector (suppressor, ASRS 300 4 mm) was used for detection. The column temperature was 30°C, while that of the detector was 35°C.
RESULTS: This method showed satisfactory reproducibility and recovery. The linear range and the correlation coefficient for both nitrite and azide ions were 0.01-0.2 mg/L and 0.9998, respectively. However, the recovery rate was 85-115% for nitrite and 90-110% for azide ions.
CONCLUSION: This method was suitable for the simultaneous determination of nitrite and azide ions in valsartan and other sartan drugs.
METHODS: Dionex IonpacAG18 (4 × 50 mm2) and Dionex IonpacAS18 (4 × 250 mm2) were used as the 2D guard column and analytical column, respectively. Dionex AMGTMC18 (4 × 30 mm2) was used as a 1D pre-separation column and Dionex UTAC-ULP1 as the concentration column. KOH solution generated by an online eluent generator (EG) was used as the 2D mobile phase, and gradient elution was performed at 1 mL/min. Water and acetonitrile were used as 1D mobile phase, and gradient elution was performed at 0.5 mL/min. Suppressed conductivity detector (suppressor, ASRS 300 4 mm) was used for detection. The column temperature was 30°C, while that of the detector was 35°C.
RESULTS: This method showed satisfactory reproducibility and recovery. The linear range and the correlation coefficient for both nitrite and azide ions were 0.01-0.2 mg/L and 0.9998, respectively. However, the recovery rate was 85-115% for nitrite and 90-110% for azide ions.
CONCLUSION: This method was suitable for the simultaneous determination of nitrite and azide ions in valsartan and other sartan drugs.