American journal of medical genetics. Part A · 2023
Impact of tracheostomies on the long-term survival of patients with trisomy 13 syndrome.
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Tamaki Shoko, Iwatani Sota, Hagimoto Shinji, Izumi Ayako, Ikuta Toshihiko, Takeoka Emiko, Matsui Sachiko, Mimura Hitomi, Minamikawa Shogo, Nakagishi Yasuo, Yoshimoto Seiji, Nakao Hideto
Аннотация
In this retrospective cohort study, we investigated the impact of tracheostomies on the long-term survival of children with trisomy 13 syndrome at a Japanese tertiary pediatric center. We compared survival and survival to discharge rates between patients who underwent tracheostomies during their NICU stays (T group, n = 8) and those who did not (non-T group, n = 11). A total of 19 patients enrolled. Median survival in all patients was 673 (266-1535) days. Significant differences in the 1-, 2-, and 3-year survival rates were found between the T and the non-T groups (100% vs. 46%, p = 0.018; 88% vs. 18%, p = 0.006; 63% vs. 9%, p = 0.041, respectively). The survival to discharge rate was higher in the T versus non-T group (75% vs. 45%, p = 0.352). This study highlights a significantly higher long-term survival of patients with trisomy 13 syndrome who underwent tracheostomies during their NICU stays.