BMJ open · 2026
Magnitude of human papillomavirus vaccination uptake and its determinants among adolescent girls in Lesotho: a cross-sectional study.
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Tebeje Tsion Mulat, Metkie Kassahun Animut, Asgedom Yordanos Sisay, Gebrekidan Amanuel Yosef, Sertsewold Seblewongel Gebretsadik, Enyew Ermias Bekele, Abebe Mesfin
Аннотация
BACKGROUND: To eliminate cervical cancer as a public health problem, the WHO recommends that human papillomavirus (HPV) vaccines should be included in national immunisation programmes and should reach 90% of all girls by age 15 as primary prevention. Lesotho reintroduced the national HPV vaccine programme in 2022.
OBJECTIVE: To investigate the prevalence and associated factors of HPV vaccination uptake among adolescent girls in Lesotho.
DESIGN: A population-based cross-sectional study design.
SETTING: Lesotho.
PARTICIPANTS: Girls aged 15-17.
PRIMARY AND SECONDARY OUTCOME MEASURES: A multilevel Poisson regression model with robust variance was applied to identify factors associated with HPV vaccination uptake. An adjusted prevalence ratio with a 95% CI was reported.
RESULTS: The uptake of HPV vaccination among adolescent girls in Lesotho was 52.15% (95% CI 48.43 to 55.84). Girls aged 16 and 17 and those residing in the Maseru district were significantly associated with a lower proportion of HPV vaccination uptake. While, ever heard of cervical cancer and ever heard of sexually transmitted infections (STIs) were found to be linked with a higher proportion of HPV vaccination uptake.
CONCLUSION: HPV vaccination uptake among adolescent girls in Lesotho was far behind the WHO 2030 target. Raising awareness about cervical cancer and HPV vaccination via targeted education is vital. A comprehensive sexual health education programme that includes information on STIs and HPV can improve vaccination uptake, especially in districts with low uptake.
OBJECTIVE: To investigate the prevalence and associated factors of HPV vaccination uptake among adolescent girls in Lesotho.
DESIGN: A population-based cross-sectional study design.
SETTING: Lesotho.
PARTICIPANTS: Girls aged 15-17.
PRIMARY AND SECONDARY OUTCOME MEASURES: A multilevel Poisson regression model with robust variance was applied to identify factors associated with HPV vaccination uptake. An adjusted prevalence ratio with a 95% CI was reported.
RESULTS: The uptake of HPV vaccination among adolescent girls in Lesotho was 52.15% (95% CI 48.43 to 55.84). Girls aged 16 and 17 and those residing in the Maseru district were significantly associated with a lower proportion of HPV vaccination uptake. While, ever heard of cervical cancer and ever heard of sexually transmitted infections (STIs) were found to be linked with a higher proportion of HPV vaccination uptake.
CONCLUSION: HPV vaccination uptake among adolescent girls in Lesotho was far behind the WHO 2030 target. Raising awareness about cervical cancer and HPV vaccination via targeted education is vital. A comprehensive sexual health education programme that includes information on STIs and HPV can improve vaccination uptake, especially in districts with low uptake.