[Therapy of endocrine diseases in childhood and adolescence. 2. Connatal athyreosis. 3. Diabetes insipidus neurohormonalis].

Congenital athyreosis may be due to different though mostly unknown factors. It should be diagnosed by TSH-screening. Immediate therapy consists of supplementation of thyroxin. The dose should be adjusted to the child's needs controlled by normal growth and bone age advance, normalization of TSH and thyroxin levels in serum. The goal must be to reach normal intelligence. Therapy should be continued during the entire life. Absence of adiuretin is the cause for diabetes insipidus neurohormonalis due to genetic disorders, tumor or infection of the hypothalamo-pituitary system. The disorder is best treated with synthetic desamino-8-vasopressin (minirin, alternatively with an oily suspension of pitressin). Diabetes insipidus renalis and psychogenic polydipsia should be ruled out before this therapy is started.