The selectivity of the anorectic effect of satietin. I. The ineffectiveness of satietin on behavioral tests.

Satietin, a potent endogenous anorectic substance separated from human serum, plays a role of a rate limiting satiety signal in the negative feed back of food intake. The selectivity of satietin on some behavioral tests (unconditioned avoidance reaction, one-way as well as two-way conditioning, open field, consolidated conditioned reflex) was checked and compared to calcitonin. TRH and Glp-Leu-Pro-OH. Satietin seemed to be ineffective on all but one (open field) behavioral tests. Calcitonin and Glp-Leu-Pro-OH increased open field activity. Results indicate that satietin is an endogenous anorectic substance with a peculiar selectivity.