Lack of effect of the peptide pyro-Glu-His-Gly-OH on food consumption in mice and rats.

1. Single subcutaneous injections (0.5-10 mg/kg) or repeated oral administration (5 mg/kg, twice daily for 3 or 5 days) of the proposed anorexigenic peptide pyro-GLU-HIS-GLY-OH did not affect food intake in the mouse. 2. Single intravenous injections (0.05-1 mg/kg) or daily intravenous injections (0.3-10 mg/kg, for 5 days) of pyro-GLU-HIS-GLY-OH did not affect food intake in the rat. 3. These results, together with results obtained recently by other workers, indicate that pyro-GLU-HIS-GLY-OH does not have anorexigenic properties in rodents.