Influence of the second coordination sphere on O2 activation by a nonheme iron(II) thiolate complex.

The synthesis and characterization of a new ligand, 1-(bis(pyridin-2-ylmethyl) amino)-2-methylpropane-2-thiolate (BPAMe2S-) and its nonheme iron complex, FeII(BPAMe2S)Br (1), is reported. Reaction of 1 with O2 at -20 °C generates a high-spin iron(III)-hydroxide complex, [FeIII(OH)(BPAMe2S)(Br)] (2), that was characterized by UV-vis, 57Fe Mössbauer, and electron paramagnetic resonance (EPR) spectroscopies, and electrospray ionization mass spectrometry (ESI-MS). Density functional theory (DFT) calculations were employed to support the spectroscopic assignments. In a previous report (J. Am. Chem. Soc.2024, 146, 7915-7921), the related iron(II) complex, FeII(BNPAMe2S)Br (BNPAMe2S- = (bis((6-(neopentylamino)pyridinyl) methyl)amino)-2-methylpropane-2-thiolate) was reported and shown to react with O2 at low temperature to give a rare iron(III)-superoxide intermediate, which then converts to an S‑oxygenated sulfinate as seen for the nonheme iron thiol dioxygenases. This complex includes two hydrogen bonding neopentylamino groups in the second coordination sphere. Complex 1 does not include these H-bonding groups, and its reactivity with O2 does not yield a stabilized Fe/O2 intermediate or S‑oxygenated products, although the data suggest an inner-sphere mechanism and formation of an iron‑oxygen species that is capable of abstracting hydrogen atoms from solvent or weak CH bond substrates. This study indicates that the H-bond donors are critical for stabilizing the FeIII(O2-•) intermediate with the BNPAMe2S- ligand, which in turn leads to S‑oxygenation, as opposed to H-atom abstraction, following O2 activation by the nonheme iron center.