Biomedical and environmental sciences : BES · 2015
Changing Grains for the Prevention and Treatment of Kashin-Beck Disease in Children: a Meta-analysis.
Письмо в редакциюМетаанализПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Han Jing, Yu Fang Fang, Chang Zai Ping, Yang Bo, Qu Cheng Juan, Zhou Tian Tian, Liu Rui Yu, Guo Xiong
Аннотация
To evaluate the efficacy of changing grains on the prevention and treatment of Kashin-Beck Disease (KBD) in children, community-based trials were acquired from seven electronic databases (up to July 2014). As a result, the methodological quality of the six trials that have been included into our analysis was low. The pooled ORs favoring the prevention and treatment effects of changing grains were 0.15 (95% CI: 0.03-0.70) and 2.13 (95% CI: 1.44-3.16) respectively by meta-analysis. Subgroup analysis demonstrated the pooled OR favoring treatment effect of exchanging grains rather than drying grains both compared with endemic grains. The results showed that changing grains had obvious effects on the prevention and treatment of KBD in children. However, the evidences were limited by the potential biases and confounders. Large and well-designed trials are still needed.