Association between serum magnesium and common complications of diabetes mellitus.

BACKGROUND

Magnesium ion, as important cation in the human body, involved in various enzymatic reactions, glucose transport and insulin release. Now diabetes mellitus and diabetic complications have become important public health problems around the world.

OBJECTIVE

This paper explores the association between concentration levels of serum magnesium and common complications and comorbidities of diabetes mellitus and other biochemical indexes.

METHODS

There are 1217 eligible patients selected from 14,317 cases of diabetic hospitalization patients from January 2010 to December 2011. Random forest algorithm was applied to assess the importance of various biochemical indexes and to perform diabetic complications prediction.

RESULTS

The research results showed that low concentration of serum magnesium and four common diabetic complications - diabetic retinopathy, diabetic nephropathy, diabetic neuropathy and diabetic macroangiopathy - exists association, but no obvious correlation with other comorbidities like hypertension.

CONCLUSIONS

The specific factors of four common diabetic complications were selected from the biochemical indexes to provide a reference direction for further research.