The influence of hepatocarcinogens on the central effects of phenobarbital an D-amphetamine.

The influence of two hepatotropic chemical carcinogens - 2-acetylaminofluorene (AAF) and N-nitrosodiethylamine (NDEA) on the processes of adrenergic activation of central synaptic structures and narcotic effect of phenobarbital was investigated. AAF and NDEA modified the stimulating effect of D-amphetamine which was demonstrated by the decrease of stereotype behavior interval and increase of its toxicity. Both carcinogens potentiated the narcotic effect of phenobarbital. The investigation of the terminal component of hepatic mixed-function oxidases system (cytochrome P-450) during carcinogen injections allows to exclude the great importance of D-amphetamine and phenobarbital metabolic variation in modification of their effects. The results of experiments assume the concept of chemical carcinogen effects on the functions of central and peripheral nervous system synaptic structures related to control of the proliferation and differentiation as initial step in hepatic carcinogenesis.