Nature aging · 2023
Transcriptional and epigenetic decoding of the microglial aging process.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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История · было → стало
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Li Xiaoyu, Li Yuxin, Jin Yuxiao, Zhang Yuheng, Wu Jingchuan, Xu Zhen, Huang Yubin, Cai Lin, Gao Shuai, Liu Taohui, Zeng Fanzhuo, Wang Yafei, Wang Wenxu, Yuan Ti-Fei, Tian Hengli, Shu Yousheng, Guo Feifan, Lu Wei, Mao Ying, Mei Xifan, Rao Yanxia, Peng Bo
Аннотация
As important immune cells, microglia undergo a series of alterations during aging that increase the susceptibility to brain dysfunctions. However, the longitudinal characteristics of microglia remain poorly understood. In this study, we mapped the transcriptional and epigenetic profiles of microglia from 3- to 24-month-old mice. We first discovered unexpected sex differences and identified age-dependent microglia (ADEM) genes during the aging process. We then compared the features of aging and reactivity in female microglia at single-cell resolution and epigenetic level. To dissect functions of aged microglia excluding the influence from other aged brain cells, we established an accelerated microglial turnover model without directly affecting other brain cells. By this model, we achieved aged-like microglia in non-aged brains and confirmed that aged-like microglia per se contribute to cognitive decline. Collectively, our work provides a comprehensive resource for decoding the aging process of microglia, shedding light on how microglia maintain brain functions.