Bone sclerosis in infancy.

The significance of bone sclerosis in infants and children as seen on X-ray examination is discussed. The recognition of increased bone density during the investigation of infants who fail to thrive may not establish the diagnosis but is important in instigating further tests. This review draws attention to the practical value of recognizing a generalized increase of bone density, especially as an incidental finding. Since the immediate reaction of growing bone to metabolic insult is limited, there is considerable overlap in the radiographic features of different conditions, but clinical and biochemical measures can then be directed towards a correct assessment.