Journal of B.U.ON. : official journal of the Balkan Union of Oncology · 2016
E-cadherin-160 C/A genotypes and cervical intraepithelial neoplasia.
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Cristina Rotar Ioana, Muresan Daniel, Elena Dumitras Diana, Popp Radu Anghel, Maria Petrisor Felicia, Stamatian Florin
Аннотация
PURPOSE: E-cadherin is a transmembrane glycoprotein with important roles in the maintenance of cervical squamous epithelium integrity. The purpose of this study was to investigate the relationship between E-cadherin-160 C/A polymorphism and cervical intraepithelial neoplasia (CIN).
METHODS: A case-control study was performed enrolling 70 CIN cases and 107 age-matched healthy controls. Each patient was examined colposcopically, having a cervical specimen. All patients and controls have been genotyped for E-cadherin-160. Data were analysed using odds ratios (OR) and chi-square test at a significance level of p<0.005.
RESULTS: The presence of E-cadherin-160 C/A was significantly associated with high-grade squamous intraepithelial lesion (HSIL) (OR=2.7916, 95% CI 1.1495,6.9345, x2=6.33, p=0.0118) and carcinoma in situ (CIS) (OR=2.5617, 95% CI 1.1676,5.6705, x2=6.63, p=0.0100). The detection of either CA or AA genotype was also significantly associated with HSIL and CIS.
CONCLUSION: E-cadherin-160 genotype represents a valid risk factor for HSIL and CIS.
METHODS: A case-control study was performed enrolling 70 CIN cases and 107 age-matched healthy controls. Each patient was examined colposcopically, having a cervical specimen. All patients and controls have been genotyped for E-cadherin-160. Data were analysed using odds ratios (OR) and chi-square test at a significance level of p<0.005.
RESULTS: The presence of E-cadherin-160 C/A was significantly associated with high-grade squamous intraepithelial lesion (HSIL) (OR=2.7916, 95% CI 1.1495,6.9345, x2=6.33, p=0.0118) and carcinoma in situ (CIS) (OR=2.5617, 95% CI 1.1676,5.6705, x2=6.63, p=0.0100). The detection of either CA or AA genotype was also significantly associated with HSIL and CIS.
CONCLUSION: E-cadherin-160 genotype represents a valid risk factor for HSIL and CIS.
Предметные рубрики MeSH
AdultAntigens, CDBiomarkers, TumorCadherinsCase-Control StudiesChi-Square DistributionColposcopyFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHeterozygoteHomozygoteHumansMiddle AgedOdds RatioPhenotypePolymorphism, GeneticPromoter Regions, GeneticRisk FactorsRomaniaSquamous Intraepithelial Lesions of the CervixUterine Cervical NeoplasmsUterine Cervical Dysplasia