The many faces of vesico-ureteric reflux: factors contributing to renal damage.

Current controversies in the pathogenesis and management of vesico-ureteric reflux (VUR) and reflux-associated nephropathy (RAN) are critically reviewed, together with the advantages and limitations of surgical correction of reflux. Special emphasis is given to pitfalls in diagnosis and ongoing reassessment, to the importance of associated urinary tract abnormalities, and to the need for continuing long term chemoprophylaxis in the presence of persisting VUR.