Pediatric research · 2019
Can social support during pregnancy affect maternal DNA methylation? Findings from a cohort of African-Americans.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Surkan Pamela J, Hong Xiumei, Zhang Boyang, Nawa Nobutoshi, Ji Hongkai, Tang Wan-Yee, Ji Yuelong, Kimmel Mary C, Wang Guoying, Pearson Colleen, Wang Xiaobin
Аннотация
BACKGROUND: While stress and the absence of social support during pregnancy have been linked to poor health outcomes, the underlying biological mechanisms are unclear.
METHODS: We examined whether adverse experiences during pregnancy alter DNA methylation (DNAm) in maternal epigenomes. Analyses included 250 African-American mothers from the Boston Birth Cohort. Genome-wide DNAm profiling was performed in maternal blood collected after delivery, using the Infinium HumanMethylation450 Beadchip. Linear regression models, with adjustment of pertinent covariates, were applied.
RESULTS: While self-reported maternal psychosocial lifetime stress and stress during pregnancy was not associated with DNAm alterations, we found that absence of support from the baby's father was significantly associated with maternal DNAm changes in TOR3A, IQCB1, C7orf36, and MYH7B and that lack of support from family and friends was associated with maternal DNA hypermethylation on multiple genes, including PRDM16 and BANKL.
CONCLUSIONS: This study provides intriguing results suggesting biological embedding of social support during pregnancy on maternal DNAm, warranting additional investigation, and replication.
METHODS: We examined whether adverse experiences during pregnancy alter DNA methylation (DNAm) in maternal epigenomes. Analyses included 250 African-American mothers from the Boston Birth Cohort. Genome-wide DNAm profiling was performed in maternal blood collected after delivery, using the Infinium HumanMethylation450 Beadchip. Linear regression models, with adjustment of pertinent covariates, were applied.
RESULTS: While self-reported maternal psychosocial lifetime stress and stress during pregnancy was not associated with DNAm alterations, we found that absence of support from the baby's father was significantly associated with maternal DNAm changes in TOR3A, IQCB1, C7orf36, and MYH7B and that lack of support from family and friends was associated with maternal DNA hypermethylation on multiple genes, including PRDM16 and BANKL.
CONCLUSIONS: This study provides intriguing results suggesting biological embedding of social support during pregnancy on maternal DNAm, warranting additional investigation, and replication.
Предметные рубрики MeSH
Adaptor Proteins, Signal TransducingAdenosine TriphosphatasesAdultBlack or African AmericanBostonCalmodulin-Binding ProteinsCardiac MyosinsCpG IslandsDNA MethylationDNA-Binding ProteinsEpigenomeEpigenomicsFathersFemaleGenome-Wide Association StudyHumansMaleMembrane ProteinsMinor Histocompatibility AntigensMolecular ChaperonesMothersMyosin Heavy ChainsOutcome Assessment, Health CarePregnancyPremature BirthRetrospective StudiesSocial ClassSocial SupportTranscription FactorsUrban PopulationYoung Adult