Salud publica de Mexico · 2003
[DDT/DDE concentrations and risk of hypospadias. Pilot case-control study].
Аннотация на английскомСтатьяПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод в очереди
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Flores-Luévano Silvia, Farías Paulina, Hernández Mauricio, Romano-Riquer Patricia, Weber Jean Philippe, Dewailly Eric, Cuevas-Alpuche Juan, Romieu Isabelle
Аннотация
OBJECTIVE: To evaluate the association between maternal serum DDT/DDE levels and risk of hypospadias.
MATERIAL AND METHODS: A case-control study in Mexico City was conducted during 1997-1999 among 41 subjects with hypospadias and 28 controls. Blood samples were obtained from study subjects. Information was obtained using a standardized questionnaire. Data were analyzed using multivariate logistic regression models.
RESULTS: Maternal DDT and DDE levels showed no association with hypospadias (OR 1.13; 95% CI 0.24-5.29 and OR = 0.48; 95% CI 0.15-1.60, respectively). Associated factors were older age of mothers (OR 8.69; 95% CI 1.69-44.9), and working during pregnancy (OR 4.68; 95% CI 1.15-18.9).
CONCLUSIONS: Information about the endocrine effects of different levels of DDT/DDE in human subjects is scarce; dosage may be a determinant factor of the type of effect. The English version of this paper is available at:http://www.insp.mx/salud/index.html.
MATERIAL AND METHODS: A case-control study in Mexico City was conducted during 1997-1999 among 41 subjects with hypospadias and 28 controls. Blood samples were obtained from study subjects. Information was obtained using a standardized questionnaire. Data were analyzed using multivariate logistic regression models.
RESULTS: Maternal DDT and DDE levels showed no association with hypospadias (OR 1.13; 95% CI 0.24-5.29 and OR = 0.48; 95% CI 0.15-1.60, respectively). Associated factors were older age of mothers (OR 8.69; 95% CI 1.69-44.9), and working during pregnancy (OR 4.68; 95% CI 1.15-18.9).
CONCLUSIONS: Information about the endocrine effects of different levels of DDT/DDE in human subjects is scarce; dosage may be a determinant factor of the type of effect. The English version of this paper is available at:http://www.insp.mx/salud/index.html.