Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2009
Genotoxicity assessment of chromium(III) propionate complex in the rat model using the comet assay.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Staniek Halina, Kostrzewska-Poczekaj Magdalena, Arndt Magdalena, Szyfter Krzysztof, Krejpcio Zbigniew
Аннотация
The aim of the study was to assess genotoxicity of a chromium(III) propionate complex in rat's peripheral blood lymphocytes by the comet assay. The study was carried out on 18 12-weeks old female Wistar rats that were divided into three equal groups (six animals each): control (0), control-Cr(VI) and Cr(III)-tested rat fed ad libitum a basal diet and the diet supplemented either with 10 mg Cr(VI)/kg diet (given as K(2)Cr(2)O(7), equivalent of 1mg/kg body mass/day) or 1000 mg Cr(III)/kg diet (given as [Cr(3)O(O(2)CCH(2)CH(3))6(H(2)O)(3)]NO(3)), equivalent of 100mg Cr/kg body mass/day) for 4 weeks. High doses of supplementary Cr(III) were found to not affect body mass gain, feeding efficiency ratio and internal organ masses. Treatment of rats with the Cr(III) propionate complex, in contrast to Cr(VI), did not affect significantly the comet assay results in lymphocytes, which suggests that the compound does not exert genotoxic effects in rats.