International journal of molecular sciences · 2021
Co-Ultra PEALut Enhances Endogenous Repair Response Following Moderate Traumatic Brain Injury.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Campolo Michela, Crupi Rosalia, Cordaro Marika, Cardali Salvatore Massimo, Ardizzone Alessio, Casili Giovanna, Scuderi Sarah Adriana, Siracusa Rosalba, Esposito Emanuela, Conti Alfredo, Cuzzocrea Salvatore
Аннотация
This study aimed to assess the neuro-regenerative properties of co-ultramicronized PEALut (Glialia®), composed of palmitoylethanolamide (PEA) and the flavonoid luteolin (Lut), in an in vivo model of traumatic brain injury (TBI) and patients affected by moderate TBI. An increase in neurogenesis was seen in the mice at 72 h and 7 d after TBI. The co-ultra PEALut treatment helped the neuronal reconstitution process to restore the basal level of both novel and mature neurons; moreover, it induced a significant upregulation of the neurotrophic factors, which ultimately led to progress in terms of memory recall during behavioral testing. Moreover, our preliminary findings in a clinical trial suggested that Glialia® treatment facilitated neural recovery on working memory. Thus, co-ultra PEALut (Glialia®) could represent a valuable therapeutic agent for intensifying the endogenous repair response in order to better treat TBI.