Global, regional, and national burden of type 1 diabetes mellitus and chronic kidney disease due to type 1 diabetes mellitus in children aged 0-14 years from 1990 to 2021.

BACKGROUND

Type 1 diabetes mellitus (T1DM) and chronic kidney disease(CKD) due to T1DM pose a substantial global health burden. However, the epidemiology of T1DM and CKD due to T1DM in children aged 0-14 years remains poorly quantified worldwide. We aimed to evaluate the global burden and trends of these conditions in this pediatric population.

METHODS

Using the Global Burden of Disease (GBD) 2021 data, we evaluated the incidence, prevalence, and disability-adjusted life years (DALYs) of T1DM and CKD due to T1DM among children aged 0-14 years from 1990 to 2021.

RESULTS

From 1990 to 2021, the global incidence number of T1DM in children aged 0-14 years increased, and the age-standardized incidence rate(ASIR) increased. The prevalence increased, the age-standardized prevalence rate(ASPR)increased, but the age-standardized DALYs rate(ASDR) decreased. The ASIR, ASPR, and ASDR of CKD due to T1DM decreased. At the same time, health inequality analysis reveals a worsening of disparities among different countries.

CONCLUSION

The global burden of T1DM and CKD due to T1DM among children aged 0-14 years is facing new challenges, highlighting the urgent need to reinforce and develop more effective public health policies and clinical prevention strategies.