Cerebellum (London, England) · 2023
Quantitative Gait and Balance Outcomes for Ataxia Trials: Consensus Recommendations by the Ataxia Global Initiative Working Group on Digital-Motor Biomarkers.
СтатьяОбзорConsensus StatementНазвание и аннотация: Перевод в очереди
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Ilg Winfried, Milne Sarah, Schmitz-Hübsch Tanja, Alcock Lisa, Beichert Lukas, Bertini Enrico, Mohamed Ibrahim Norlinah, Dawes Helen, Gomez Christopher M, Hanagasi Hasmet, Kinnunen Kirsi M, Minnerop Martina, Németh Andrea H, Newman Jane, Ng Yi Shiau, Rentz Clara, Samanci Bedia, Shah Vrutangkumar V, Summa Susanna, Vasco Gessica, McNames James, Horak Fay B, Ataxia Global Initiative (AGI) working group Digital Motor Biomarkers
Аннотация
With disease-modifying drugs on the horizon for degenerative ataxias, ecologically valid, finely granulated, digital health measures are highly warranted to augment clinical and patient-reported outcome measures. Gait and balance disturbances most often present as the first signs of degenerative cerebellar ataxia and are the most reported disabling features in disease progression. Thus, digital gait and balance measures constitute promising and relevant performance outcomes for clinical trials.This narrative review with embedded consensus will describe evidence for the sensitivity of digital gait and balance measures for evaluating ataxia severity and progression, propose a consensus protocol for establishing gait and balance metrics in natural history studies and clinical trials, and discuss relevant issues for their use as performance outcomes.