Archives of medical research · 2026
Epidemiologic Characterization and Risk Factors of Rocky Mountain Spotted Fever in Children in Northeastern Mexico: A Retrospective Cross-sectional Study (2018-2024).
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Bejarano José Iván Castillo, González Érika Aidé Larragoity, González Susana Patricia Cantú, de Los Santos Abiel Homero Mascareñas, Pérez Rodrigo García, Rosales-González Sara Paulina, Lara Diego Armando Alvarado, Ramírez María Fernanda Cid, Mariscal Alfredo Castillo, Aparicio Denisse Natalie Vaquera
Аннотация
BACKGROUND: Rocky Mountain spotted fever (RMSF) is a vector-borne disease with nonspecific symptoms, including fever, headache, myalgia, and exanthema, which complicates timely diagnosis and treatment. Despite its significant morbidity and mortality, epidemiological data and risk factor analyses remain scarce in Mexico.
METHODS: A retrospective cross-sectional study was conducted from 2018-2024 in three hospitals in northeastern Mexico. We analyzed 90 pediatric patients with confirmed rickettsiosis via polymerase chain reaction (PCR) or immunofluorescence assay (IFA). Demographic, clinical, and laboratory data were evaluated to identify independent risk factors associated with disease severity and outcomes. Statistical analyses included logistic regression, Mann-Whitney U tests, and Pearson χ2 tests (p ≤0.05).
RESULTS: School-aged children comprised 46.6% of cases, with a predominance of females (54.4%). Key epidemiological exposures included tick bites (17.8%) and pet cohabitation (54.5%). Delayed doxycycline treatment (>5 d after symptom onset) was associated with increased mortality. Significant predictors of poor outcomes were neurological impairment (OR: 3.7, CI: 1.9-7.3), shock upon admission (OR: 4.5, CI: 2.2-9.1), and thrombocytopenia (p <0.001). The overall mortality rate was 36.7%.
CONCLUSIONS: Our findings underscore the significant clinical impact of rickettsioses in northeastern Mexico and the need to improve diagnostic capabilities, raising public awareness, and implementing effective vector control programs. Early recognition and timely doxycycline treatment are crucial to improving patient outcomes. Strengthening public health strategies through preventive measures and clinician education could reduce the morbidity and mortality associated with these infections.
METHODS: A retrospective cross-sectional study was conducted from 2018-2024 in three hospitals in northeastern Mexico. We analyzed 90 pediatric patients with confirmed rickettsiosis via polymerase chain reaction (PCR) or immunofluorescence assay (IFA). Demographic, clinical, and laboratory data were evaluated to identify independent risk factors associated with disease severity and outcomes. Statistical analyses included logistic regression, Mann-Whitney U tests, and Pearson χ2 tests (p ≤0.05).
RESULTS: School-aged children comprised 46.6% of cases, with a predominance of females (54.4%). Key epidemiological exposures included tick bites (17.8%) and pet cohabitation (54.5%). Delayed doxycycline treatment (>5 d after symptom onset) was associated with increased mortality. Significant predictors of poor outcomes were neurological impairment (OR: 3.7, CI: 1.9-7.3), shock upon admission (OR: 4.5, CI: 2.2-9.1), and thrombocytopenia (p <0.001). The overall mortality rate was 36.7%.
CONCLUSIONS: Our findings underscore the significant clinical impact of rickettsioses in northeastern Mexico and the need to improve diagnostic capabilities, raising public awareness, and implementing effective vector control programs. Early recognition and timely doxycycline treatment are crucial to improving patient outcomes. Strengthening public health strategies through preventive measures and clinician education could reduce the morbidity and mortality associated with these infections.