Journal of occupational and environmental medicine · 2016
Transcriptional Pathways Altered in Response to Vibration in a Model of Hand-Arm Vibration Syndrome.
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Waugh Stacey, Kashon Michael L, Li Shengqiao, Miller Gerome R, Johnson Claud, Krajnak Kristine
Аннотация
OBJECTIVE: The aim of this study was to use an established model of vibration-induced injury to assess frequency-dependent changes in transcript expression in skin, artery, and nerve tissues.
METHODS: Transcript expression in tissues from control and vibration-exposed rats (4 h/day for 10 days at 62.5, 125, or 250 Hz; 49 m/s, rms) was measured. Transcripts affected by vibration were used in bioinformatics analyses to identify molecular- and disease-related pathways associated with exposure to vibration.
RESULTS: Analyses revealed that cancer-related pathways showed frequency-dependent changes in activation or inhibition. Most notably, the breast-related cancer-1 pathway was affected. Other pathways associated with breast cancer type 1 susceptibility protein related signaling, or associated with cancer and cell cycle/cell survivability were also affected.
CONCLUSION: Occupational exposure to vibration may result in DNA damage and alterations in cell signaling pathways that have significant effects on cellular division.
METHODS: Transcript expression in tissues from control and vibration-exposed rats (4 h/day for 10 days at 62.5, 125, or 250 Hz; 49 m/s, rms) was measured. Transcripts affected by vibration were used in bioinformatics analyses to identify molecular- and disease-related pathways associated with exposure to vibration.
RESULTS: Analyses revealed that cancer-related pathways showed frequency-dependent changes in activation or inhibition. Most notably, the breast-related cancer-1 pathway was affected. Other pathways associated with breast cancer type 1 susceptibility protein related signaling, or associated with cancer and cell cycle/cell survivability were also affected.
CONCLUSION: Occupational exposure to vibration may result in DNA damage and alterations in cell signaling pathways that have significant effects on cellular division.
Предметные рубрики MeSH
AnimalsArteriesAtaxia Telangiectasia Mutated ProteinsCell CycleCell SurvivalComputational BiologyCyclin-Dependent Kinase 5Disease Models, AnimalHand-Arm Vibration SyndromeMaleOligonucleotide Array Sequence AnalysisPeripheral NervesRNARatsRats, Sprague-DawleySignal TransductionSkinTranscription, GeneticUbiquitin-Protein LigasesVibration