International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2025
Post-infectious Guillain-Barré syndrome during a cholera outbreak in Yemen: A pediatric case with confirmed Campylobacter exposure.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Nasser Abdullah, Bagnaf Maryam Salem Awadh, Salem Faten Awadh Abdullah, Saif Maram Tariq Said, Abdullah Wafaa Salem Ali, Frasca Stefano, Zakham Fathiah, Roggenbuck Dirk
Аннотация
Yemen's prolonged conflict and fragile healthcare infrastructure have created a setting where infectious diseases like cholera frequently overlap with under-recognized post-infectious autoimmune conditions. In this context, we report a pediatric case of Guillain-Barré syndrome (GBS) following recent Campylobacter jejuni infection during a laboratory-confirmed cholera outbreak in rural Southern Yemen. The 12-year-old patient presented with acute flaccid paralysis and respiratory failure after a diarrheal illness consistent with cholera. Nerve conduction studies supported the GBS diagnosis, and advanced serological testing confirmed prior C. jejuni exposure with strong anti-GD1b IgG positivity. The case underscores the role of molecular mimicry in GBS pathogenesis, diagnostic challenges in low-resource settings, and the importance of international collaboration in confirming immune-mediated neurological diseases during simultaneous epidemics.