Why savannah monitor lizards hyperventilate during activity: a comparison of model predictions and experimental data.

The functional and structural factors that limit maximal oxygen uptake (VO2 max) in lizards are not completely understood. Using an integrative model describing the interactive nature of the individual oxygen transport conductances, we performed an analysis of the oxygen transport system in the highly aerobic lizard Varanus exanthematicus with specific reference to the sensitivity of VO2 max to potential limitations in the ventilatory system. Our analysis predicts that DLO2 must increase more than three-fold at VO2 max and even with this increase in DLO2 , the VO2 max may be sensitive to factors that alter lung ventilation and/or lower lung PO2. To test the predictions of the model analysis, we experimentally determined the effects of reducing inspired O2 on VO2 max during treadmill exercise. We conclude from both our theoretical and experimental analyses that V. exanthematicus operates near the functional limits of its lung.