COVID-19 and its impact on the cardiovascular system.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Khawaja Saud Ahmed, Mohan Poornima, Jabbour Richard, Bampouri Theodora, Bowsher Gemma, Hassan Ahmed M M, Huq Farhan, Baghdasaryan Lilit, Wang Brian, Sethi Amarjit, Sen Sayan, Petraco Ricardo, Ruparelia Neil, Nijjer Sukhjinder, Malik Iqbal, Foale Rodney, Bellamy Michael, Kooner Jaspal, Rana Bushra, Cole Graham, Sutaria Nilesh, Kanaganayagam Gajen, Nihoyannopoulos Petros, Fox Kevin, Plymen Carla, Pabari Punam, Howard Luke, Davies Rachel, Haji Gulammehdi, Lo Giudice Francesco, Kanagaratnam Prapa, Anderson Jon, Chukwuemeka Andrew, Khamis Ramzi, Varnava Amanda, Baker Christopher S R, Francis Darrel Parthipan, Asaria Perviz, Al-Lamee Rasha, Mikhail Ghada W
Аннотация
METHODS: We retrospectively analysed 498 COVID-19 positive adult admissions to our institute from 7 March to 7 April 2020. Patient data were collected for baseline demographics, comorbidities and in-hospital outcomes, especially relating to cardiovascular intervention.
RESULTS: Mean age was 67.4±16.1 years and 62.2% (n=310) were male. 64.1% (n=319) of our cohort had underlying cardiovascular disease (CVD) with 53.4% (n=266) having hypertension. 43.2%(n=215) developed acute myocardial injury. Mortality was significantly increased in those patients with myocardial injury (47.4% vs 18.4%, p<0.001). Only four COVID-19 patients had invasive coronary angiography, two underwent percutaneous coronary intervention and one required a permanent pacemaker implantation. 7.0% (n=35) of patients had an inpatient echocardiogram. Acute myocardial injury (OR 2.39, 95% CI 1.31 to 4.40, p=0.005) and history of hypertension (OR 1.88, 95% CI 1.01 to 3.55, p=0.049) approximately doubled the odds of in-hospital mortality in patients admitted with COVID-19 after other variables had been controlled for.
CONCLUSION: Hypertension, pre-existing CVD and acute myocardial injury were associated with increased in-hospital mortality in our cohort of COVID-19 patients. However, only a low number of patients required invasive cardiac intervention.