Molecules (Basel, Switzerland) · 2019
Bioactive 2-(Methyldithio)Pyridine-3-Carbonitrile from Persian Shallot (Allium stipitatum Regel.) Exerts Broad-Spectrum Antimicrobial Activity.
СтатьяНазвание и аннотация: Перевод в очереди
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Karunanidhi Arunkumar, Ghaznavi-Rad Ehsanollah, Jeevajothi Nathan Jayakayatri, Joseph Narcisse, Chigurupati Sridevi, Mohd Fauzi Fazlin, Pichika Mallikarjuna Rao, Hamat Rukman Awang, Lung Leslie Than Thian, van Belkum Alex, Neela Vasanthakumari
Аннотация
Antibiotic resistance is a problem that continues to challenge the healthcare sector, especially in clinically significant pathogens like methicillin-resistant Staphylococcus aureus (MRSA). Herein is described the isolation and structure elucidation of a bioactive compound from Allium stipitatum with antimicrobial activity. Crude Allium stipitatum dichloromethane extract (ASDE) was subjected to systematic purification by chromatographic procedures to afford various bioactive fractions. A fraction that exhibited anti-MRSA activity (4 µg·mL-1) was further characterized to determine the structure. The structure of the compound was elucidated as 2-(methyldithio)pyridine-3-carbonitrile (2-Medpy-3-CN). The 2-Medpy-3-CN compound, which was screened for antimicrobial activity, exhibited minimum inhibitory concentrations (MICs) in the range of 0.5 to >64 µg·mL-1 for tested bacterial species and 0.25 to 2 µg·mL-1 for Candida spp. Further studies are important to confirm the drug target and mechanism of action.