[Pain in multimorbid internistic patients].

Pain and pain management in multimorbid patients is a subject which is mostly unknown. General rules in pain management like the WHO analgesic ladder and its recommendations are to be equally respected as with other patients. As multimorbidity is a common problem especially in the elderly population, some changes in physiology, pharmacodynamics and pharmacokinetics have to be taken into consideration. A careful and slow adoption of dosage leads to more safety and tolerability. Other main problems of multimorbidity are drug-drug, drug-disease or disease-disease interactions, which influence the choice of analgesic medication. As especially the number of drug-drug interactions is endless, available software is a valuable aid to become aware of interactions and help weight the compromises.