Emerging infectious diseases · 2025
Scheffersomyces spartinae Fungemia among Pediatric Patients, Pakistan, 2020-2024.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Jabeen Kauser, Farooqi Joveria, Simons Lacy M, Hultquist Judd F, Lorenzo-Redondo Ramon, Evans Charlesnika T, Hartmann Erica M, Hanif Mohammad, Hasan Zahra, Mahmood Syed Faisal, Ashraf Javaria, Ghayas Hassan, Zaka Sadaf, Saeed Noureen, Bukhari Sayed Ali Raza Shah, Arshad Mehreen, Kociolek Larry K, Patel Sameer J, Hasan Rumina, Ozer Egon A
Аннотация
Prevalence of emerging fungal infections is increasing, particularly among immunocompromised persons, children, and older persons. We report 108 cases of Scheffersomyces spartinae infection in pediatric patients from Karachi and other cities in Pakistan, of which 107 were identified from blood cultures. Cultures were initially misidentified as Clavispora lusitaniae by a biochemical assay before speciation as S. spartinae by whole-genome sequencing. All isolates were from children <12 years of age, and >69% were from children <1 month of age. Isolates were genetically distinct across regions of Pakistan; however, genetic diversity was low in isolates from patients in Karachi and nearby Nawabshah and had median differences of just 9 pairwise nucleotide variants. This study demonstrates S. spartinae is a potentially emerging pathogen in neonates and young infants in Pakistan. The findings highlight the limitations of phenotypic identification for detecting emerging fungal infections and underscore the value of molecular identification approaches.