Current osteoporosis reports · 2020
Bone Muscle Crosstalk in Spinal Cord Injuries: Pathophysiology and Implications for Patients' Quality of Life.
СтатьяПоддержка исследования: вне правительства СШАОбзорНазвание и аннотация: Перевод в очереди
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Invernizzi Marco, de Sire Alessandro, Carda Stefano, Venetis Konstantinos, Renò Filippo, Cisari Carlo, Fusco Nicola
Аннотация
PURPOSE OF REVIEW: The goal of this review is to provide a comprehensive overview of (i) bone and muscle tissue modifications pathophysiology in spinal cord injury (SCI), (ii) experimental data on the physiopathological mechanisms underpinning these modifications and their similarities with the aging process, and (iii) potential clinical implications in the management of the disabling sequelae of SCI.
RECENT FINDINGS: Several studies attempted to describe the biology underpinning the links between bone and muscle tissues in the setting of highly disabling conditions, such as osteoporosis, sarcopenia, and neurodegenerative disorders, although these bidirectional connections remain still unclear. SCI could be considered an in vivo paradigmatic model of the bone muscle interactions in unloading conditions that might be expanded in the field of neurodegenerative disorders or cancer studies. Future studies should take into consideration the newer insights into bone muscle crosstalk in order to develop multitargeted and therapeutic interventions.
RECENT FINDINGS: Several studies attempted to describe the biology underpinning the links between bone and muscle tissues in the setting of highly disabling conditions, such as osteoporosis, sarcopenia, and neurodegenerative disorders, although these bidirectional connections remain still unclear. SCI could be considered an in vivo paradigmatic model of the bone muscle interactions in unloading conditions that might be expanded in the field of neurodegenerative disorders or cancer studies. Future studies should take into consideration the newer insights into bone muscle crosstalk in order to develop multitargeted and therapeutic interventions.
Предметные рубрики MeSH
Adaptor Proteins, Signal TransducingAdipokinesAminoisobutyric AcidsBone and BonesCell Adhesion MoleculesCollagenFibroblast Growth FactorsFibronectinsHumansInsulin-Like Growth Factor IInterleukin-6Mitochondria, MuscleMuscle, SkeletalMyostatinOsteocytesOsteogenesisQuality of LifeSpinal Cord InjuriesWeight-Bearing