[Neonatal brain hypothermia].

The neonatal brain hypothermia is one of the effective therapies for neonatal hypoxic-ischemic encephalopathy (HIE). The brain hypothermia is thought to protect the brain from the secondary energy failure after hypoxic-ischemic injury at asphyxia. Some literature wrote the effect for neuronal protection for HIE, but the effect is insufficient for severe one. In severe HIE, the basal ganglia regions are injured with ischemic change in the brain MRI findings and occurred the severe permanent handicaps. I think that the reason for fragile of basal ganglia region are related to the existence of NMDA receptor. So, we have to study and develop the new strategy for neuronal protection in HIE.