Diagnostic Value of Platelet Count, Alanine Aminotransferase, and Fibrinogen in Differentiating Incomplete Kawasaki Disease from Sepsis.

OBJECTIVE

The aim of this study is to compare laboratory parameters between incomplete Kawasaki disease (IKD) and sepsis, and to evaluate the predictive value of common laboratory parameters in distinguishing IKD from sepsis.

METHODS

A retrospective analysis was conducted on medical records of patients diagnosed with Kawasaki disease or sepsis between January 2021 and December 2023. A total of 207 cases of IKD and 315 cases of sepsis were included in this study. Clinical data were analyzed to identify intergroup differences.

RESULTS

Significant intergroup differences ( P  < 0.05) were observed in blood platelet (PLT) count, procalcitonin, aspartate aminotransferase, alanine aminotransferase (ALT), urea nitrogen, creatinine, C-reactive protein, fibrinogen (Fib), and D-dimer levels. Markers with statistically significant variations relevant to the diagnosis of IKD were identified using binary logistic regression analysis. Receiver operating characteristic curve analysis demonstrated areas under the curve of 0.771 for PLT, 0.800 for ALT, and 0.755 for Fib. A combined assessment of these markers resulted in improved sensitivity and specificity.

CONCLUSION

PLT, ALT, and Fib can serve as laboratory markers for distinguishing IKD from sepsis and offer diagnostic reference value. Their combined assessment may improve the predictive accuracy for IKD.