Clinical management of osteogenesis imperfecta.

Knowledge of the natural history of different types of OI permits planning of rehabilitation goals for children with OI. Notwithstanding this knowledge, rehabilitation will need to be modified to accommodate unexpected fractures and the highly variable chance of deformity in each individual. Immobilisation should be minimized to avoid immobilization osteoporosis. New rehabilitation issues include basilar impression, recommencement of fractures in postmenopausal women with OI, pregnancy related bone loss and sleep apnoea.