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DOI 10.1038/nature18637

Медицинская библиотека · Nature · 2016

A comprehensive transcriptional map of primate brain development.

Bakken Trygve E, Miller Jeremy A, Ding Song-Lin, Sunkin Susan M, Smith Kimberly A, Ng Lydia, Szafer Aaron, Dalley Rachel A, Royall Joshua J, Lemon Tracy, Shapouri Sheila, Aiona Kaylynn, Arnold James, Bennett Jeffrey L, Bertagnolli Darren, Bickley Kristopher, Boe Andrew, Brouner Krissy, Butler Stephanie, Byrnes Emi, Caldejon Shiella, Carey Anita, Cate Shelby, Chapin Mike, Chen Jefferey, Dee Nick, Desta Tsega, Dolbeare Tim A, Dotson Nadia, Ebbert Amanda, Fulfs Erich, Gee Garrett, Gilbert Terri L, Goldy Jeff, Gourley Lindsey, Gregor Ben, Gu Guangyu, Hall Jon, Haradon Zeb, Haynor David R, Hejazinia Nika, Hoerder-Suabedissen Anna, Howard Robert, Jochim Jay, Kinnunen Marty, Kriedberg Ali, Kuan Chihchau L, Lau Christopher, Lee Chang-Kyu, Lee Felix, Luong Lon, Mastan Naveed, May Ryan, Melchor Jose, Mosqueda Nerick, Mott Erika, Ngo Kiet, Nyhus Julie, Oldre Aaron, Olson Eric, Parente Jody, Parker Patrick D, Parry Sheana, Pendergraft Julie, Potekhina Lydia, Reding Melissa, Riley Zackery L, Roberts Tyson, Rogers Brandon, Roll Kate, Rosen David, Sandman David, Sarreal Melaine, Shapovalova Nadiya, Shi Shu, Sjoquist Nathan, Sodt Andy J, Townsend Robbie, Velasquez Lissette, Wagley Udi, Wakeman Wayne B, White Cassandra, Bennett Crissa, Wu Jennifer, Young Rob, Youngstrom Brian L, Wohnoutka Paul, Gibbs Richard A, Rogers Jeffrey, Hohmann John G, Hawrylycz Michael J, Hevner Robert F, Molnár Zoltán, Phillips John W, Dang Chinh, Jones Allan R, Amaral David G, Bernard Amy, Lein Ed S

СтатьяПоддержка NIH: внешняя программаПеревод в очереди

Аннотация

The transcriptional underpinnings of brain development remain poorly understood, particularly in humans and closely related non-human primates. We describe a high-resolution transcriptional atlas of rhesus monkey (Macaca mulatta) brain development that combines dense temporal sampling of prenatal and postnatal periods with fine anatomical division of cortical and subcortical regions associated with human neuropsychiatric disease. Gene expression changes more rapidly before birth, both in progenitor cells and maturing neurons. Cortical layers and areas acquire adult-like molecular profiles surprisingly late in postnatal development. Disparate cell populations exhibit distinct developmental timing of gene expression, but also unexpected synchrony of processes underlying neural circuit construction including cell projection and adhesion. Candidate risk genes for neurodevelopmental disorders including primary microcephaly, autism spectrum disorder, intellectual disability, and schizophrenia show disease-specific spatiotemporal enrichment within developing neocortex. Human developmental expression trajectories are more similar to monkey than rodent, although approximately 9% of genes show human-specific regulation with evidence for prolonged maturation or neoteny compared to monkey.

Для цитирования: Bakken Trygve E, Miller Jeremy A, Ding Song-Lin, Sunkin Susan M, Smith Kimberly A, Ng Lydia, Szafer Aaron, Dalley Rachel A, Royall Joshua J, Lemon Tracy, Shapouri Sheila, Aiona Kaylynn, Arnold James, Bennett Jeffrey L, Bertagnolli Darren, Bickley Kristopher, Boe Andrew, Brouner Krissy, Butler Stephanie, Byrnes Emi, Caldejon Shiella, Carey Anita, Cate Shelby, Chapin Mike, Chen Jefferey, Dee Nick, Desta Tsega, Dolbeare Tim A, Dotson Nadia, Ebbert Amanda, Fulfs Erich, Gee Garrett, Gilbert Terri L, Goldy Jeff, Gourley Lindsey, Gregor Ben, Gu Guangyu, Hall Jon, Haradon Zeb, Haynor David R, Hejazinia Nika, Hoerder-Suabedissen Anna, Howard Robert, Jochim Jay, Kinnunen Marty, Kriedberg Ali, Kuan Chihchau L, Lau Christopher, Lee Chang-Kyu, Lee Felix, Luong Lon, Mastan Naveed, May Ryan, Melchor Jose, Mosqueda Nerick, Mott Erika, Ngo Kiet, Nyhus Julie, Oldre Aaron, Olson Eric, Parente Jody, Parker Patrick D, Parry Sheana, Pendergraft Julie, Potekhina Lydia, Reding Melissa, Riley Zackery L, Roberts Tyson, Rogers Brandon, Roll Kate, Rosen David, Sandman David, Sarreal Melaine, Shapovalova Nadiya, Shi Shu, Sjoquist Nathan, Sodt Andy J, Townsend Robbie, Velasquez Lissette, Wagley Udi, Wakeman Wayne B, White Cassandra, Bennett Crissa, Wu Jennifer, Young Rob, Youngstrom Brian L, Wohnoutka Paul, Gibbs Richard A, Rogers Jeffrey, Hohmann John G, Hawrylycz Michael J, Hevner Robert F, Molnár Zoltán, Phillips John W, Dang Chinh, Jones Allan R, Amaral David G, Bernard Amy, Lein Ed S. A comprehensive transcriptional map of primate brain development.. Nature. 2016. DOI: 10.1038/nature18637.

Предметные рубрики MeSH

AgingAnimalsAutism Spectrum DisorderBrainCell AdhesionConserved SequenceFemaleHumansIntellectual DisabilityMacaca mulattaMaleMicrocephalyNeocortexNeurodevelopmental DisordersNeurogenesisRisk FactorsSchizophreniaSpatio-Temporal AnalysisSpecies SpecificityTranscription, GeneticTranscriptome
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