A multi-center study on the prophylactic application of antibiotics in aseptic operations.

To understand the application of antibacterial agents in aseptic operations and to provide evidence for their rational use and management, the antibiotic use statuses of six types of aseptic operations (306 cases from 4 tertiary hospitals) were retrospectively analyzed. Of 312 patients, 306 (65.08%) were treated with antibacterial agents in the perioperative period. Four categories of antibiotics including cephalosporins, penicillins, nitroimidazoles, and fluoroquinolones were administered (descending sequence). Administration time: preoperative >2 h, 15 cases; preoperative 0.5-2 h, 20 cases; postoperative: 265 cases. Drug withdrawal time: postoperative 1-3 days: 33 cases; 3-7 days: 255 cases; 7-15 days: 12 cases. The prophylactic use of antibacterial agents in aseptic operations suffers from non-strict mastered medication indication, improper drug selection, aimless drug combinations, inappropriate administration timing, and over long medication duration.