[Genome-wide association studies on the developmental dyslexia children].

OBJECTIVE

To find out the potential polymorphisms of gene with developmental dyslexia children.

METHODS

From January 2010 to December 2013, 121 cases children with developmental dyslexia and 117 cases health children as the control were enrolled into the study. The potential polymorphisms of gene were found by case-control study strategies based on the Affymetrix Genome-Wide SNP 6. 0 microarray and pathway analysis.

RESULTS

Genotypes and allele frequencies of rs331142 and rs12495133 from DYX1C1 gene, rs11629841 and rs3743205 from ROBOl gene between cases and control groups were significantly different (P < 0. 05).

CONCLUSION

Polymorphism of rs331142 and rs12495133 from DYX1C1 gene, rs11629841 and rs3743205 from ROB01 gene may associate with developmental dyslexia children.