DOI 10.3760/cma.j.issn.1003-9406.2012.02.020

Медицинская библиотека · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics · 2012

[Association between rs6658835 polymorphism of transforming growth factor beta 2 gene and congenital heart diseases in Chinese Han population].

Xie Jun, Chen Yu, Li Hui, Zhou Bin, Rao Li

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

OBJECTIVE

To assess the association between a tag single nucleotide polymorphism (rs6658835) of transforming growth factor beta 2 (TGF beta2) gene and congenital heart disease (CHD) in Chinese Han population.

METHODS

A total of 324 CHD cases including 144 atrial septal defects (ASD), 88 patent ductus arteriosus (PDA), 92 ventricular septal defects (VSD) and 158 healthy controls were enrolled. The genotype of rs6658835 was determined by polymerase chain reaction-restriction fragment length polymorphism assay.

RESULTS

The genotypic and allelic frequencies of rs6658835 were associated with VSD (P< 0.05), but not with ASD or PDA (P> 0.05).

CONCLUSION

The rs6658835 polymorphism of TGF beta 2 gene is associated with the susceptibility of VSD in Chinese Han population.

Для цитирования: Xie Jun, Chen Yu, Li Hui, Zhou Bin, Rao Li. [Association between rs6658835 polymorphism of transforming growth factor beta 2 gene and congenital heart diseases in Chinese Han population].. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. 2012. DOI: 10.3760/cma.j.issn.1003-9406.2012.02.020.

Предметные рубрики MeSH

Adolescent Adult Asian People Child Female Genetic Predisposition to Disease Heart Defects, Congenital Humans Male Middle Aged Polymorphism, Single Nucleotide Transforming Growth Factor beta2 Young Adult

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