Transactions of the Royal Society of Tropical Medicine and Hygiene · 2025
Genetic markers at the crossroads: toll-like receptor polymorphisms and Plasmodium vivax malaria parasitological aspects from the Brazil-French Guiana border.
СтатьяПоддержка исследования: вне правительства СШАПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Cerilo-Filho Marcelo, Ramirez Aína D R, Barbosa Vanessa S, Correa Renata B, de Jesus Myrela C S, Sampaio Marrara P, Miceli Leonardo A, Reis Nathália F, Menezes Rubens A O, Gomes Margarete S M, Pimenta Tamirys S, Cassiano Gustavo C, Silva José R S, Storti-Melo Luciane M, Baptista Andrea R S, Machado Ricardo L D
Аннотация
BACKGROUND: Studies relating allelic variants in toll-like receptor (TLR) genes to the parasitological profile of Plasmodium vivax malaria are scarce. Therefore, we sought to assess whether polymorphisms in these genes can influence the clinical and parasitological aspects of individuals with P. vivax malaria in an endemic area from the Brazil-French Guiana border.
METHODS: We analyzed 76 patients with P. vivax malaria. Parasitological parameters were collected, and genomic DNA was extracted from whole blood. The single nucleotide polymorphisms (SNPs) of TLR4 (rs4986790, rs4986791), TLR6 (rs5743810) and TLR9 genes (rs187084, rs5743836) were genotyped by qPCR. Association between the levels of parasitemia and gametocytes with the SNPs was performed using Kruskal-Wallis and Mann-Whitney tests. Parasitemia and gametocyte levels were adjusted for the polymorphisms using a linear regression model.
RESULTS: There was a correlation between the TLR4 rs4986790, TLR6 rs5743810 and TLR9 rs187084 SNPs and parasitological aspects.
CONCLUSIONS: The results described here suggest that these genes' polymorphisms may have a role in the development of the inflammatory response during P. vivax malaria. The potential implications of these findings are discussed.
METHODS: We analyzed 76 patients with P. vivax malaria. Parasitological parameters were collected, and genomic DNA was extracted from whole blood. The single nucleotide polymorphisms (SNPs) of TLR4 (rs4986790, rs4986791), TLR6 (rs5743810) and TLR9 genes (rs187084, rs5743836) were genotyped by qPCR. Association between the levels of parasitemia and gametocytes with the SNPs was performed using Kruskal-Wallis and Mann-Whitney tests. Parasitemia and gametocyte levels were adjusted for the polymorphisms using a linear regression model.
RESULTS: There was a correlation between the TLR4 rs4986790, TLR6 rs5743810 and TLR9 rs187084 SNPs and parasitological aspects.
CONCLUSIONS: The results described here suggest that these genes' polymorphisms may have a role in the development of the inflammatory response during P. vivax malaria. The potential implications of these findings are discussed.