Oral surgery, oral medicine, oral pathology and oral radiology · 2025
A clinical evaluation of the efficacy of montelukast in alleviating postoperative nasal congestion after bimaxillary orthognathic surgery.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Goharian Rozhin Kafshdar, Samieirad Sahand, Jafari Mahdi, Grillo Ricardo
Аннотация
OBJECTIVE: The aim of this study was to evaluate the effect of oral montelukast administration on postoperative nasal congestion following orthognathic surgery.
METHODS: Patients who underwent bimaxillary orthognathic surgery were enrolled in this triple-blind clinical trial. Rhinomanometry testing was performed to assess postoperative nasal congestion. Each patient received a 10 mg tablet of montelukast 1 hour before surgery and daily for 1 week thereafter, in comparison to a placebo group. After 1 week, rhinomanometry testing was conducted for both groups to evaluate postoperative nasal congestion. For statistical analysis, the significance level was set at 5%, using paired and independent t tests.
RESULTS: A total of 44 patients with an average age of 26.98 ± 4.78 years were included. The average postoperative nasal airflow during both inhalation and exhalation was significantly higher in the montelukast group (P < .001). Additionally, the mean postoperative nasal resistance during both inhalation and exhalation was significantly lower in the montelukast group (P < .001).
CONCLUSIONS: Oral administration of montelukast appears to be effective in reducing nasal congestion following orthognathic surgery.
METHODS: Patients who underwent bimaxillary orthognathic surgery were enrolled in this triple-blind clinical trial. Rhinomanometry testing was performed to assess postoperative nasal congestion. Each patient received a 10 mg tablet of montelukast 1 hour before surgery and daily for 1 week thereafter, in comparison to a placebo group. After 1 week, rhinomanometry testing was conducted for both groups to evaluate postoperative nasal congestion. For statistical analysis, the significance level was set at 5%, using paired and independent t tests.
RESULTS: A total of 44 patients with an average age of 26.98 ± 4.78 years were included. The average postoperative nasal airflow during both inhalation and exhalation was significantly higher in the montelukast group (P < .001). Additionally, the mean postoperative nasal resistance during both inhalation and exhalation was significantly lower in the montelukast group (P < .001).
CONCLUSIONS: Oral administration of montelukast appears to be effective in reducing nasal congestion following orthognathic surgery.