COVID- 19 in patients affected by red blood cell disorders, results from the European registry ERN-EuroBloodNet.
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Velasco Puyo Pablo, Christou Soteroula, Campisi Saveria, Rodríguez-Sánchez Maria A, Reidel Sara, Perez-Hoyo Santiago, Mota Miriam, Savvidou Irene, Rekleiti Anna, Salvo Alessandra, Voi Vincenzo, Ferrero Giovanni Battista, Mandrile Giorgia, Gaglioti Carmen Maria, Cela Elena, Ponce-Salas Beatriz, Bardón-Cancho Eduardo J, Flevari Pagona, Voskaridou-Dimoula Ersi, Nur Erfan, Biemond Bart J, Delaporta Polynexi, Beneitez-Pastor David, Collado Gimbert Anna, Spasiano Anna, Besse-Hammer Tatiana, Lafiatis Ioannis G, Dedeken Laurence, Raso Simona, Ruiz-Llobet Anna, Bagnato Sabrina, Labarque Veerle, Glenthøj Andreas, Ruffo Giovan Battista, Guerzoni Maria Elena, Hafraoui Kaoutar, Pistoia Laura, Rosso Rosamaria, Tagliaferri Laura, Gonzalez-Urdiales Paula, Benghiat Fleur Samantha, de Montalembert Mariane, Teles Maria Jose, Vanderfaeillie Anna, Bertoni Elisa, Cuzzubbo Daniela, Ferreira Teresa, Saunders Christopher J, Stiakaki Eftichia, Van de Velde Ann L, Diamantidis Michael D, Kerkhoffs Jean-Louis H, Oliveira Marisa I, Quota Alessandra, Russo Roberta, Van Damme An, Argüello Marina María, Lorite Reggiori Mikael, Rijneveld Anita W, Rodríguez Gallego Alexis, Colombatti Raffaella, Iolascon Achille, Taher Ali, Gulbis Béatrice, Roy Noémi B A, Mañú-Pereira María Del Mar
Аннотация
PROCEDURES: The study evaluated patient distribution, the infection across different RBCDs, and severity risk factors across similar healthcare systems, using data collected from the ERN-EuroBloodNet's REDCap platform.
RESULTS: From April 2020 to April 2023, 681 infections were recorded among 663 patients, of which 373 had transfusion-dependent thalassemia or non-transfusion-dependent thalassemia (TDT/NTDT), and 269 had sickle cell disease (SCD). SCD patients had a higher incidence of COVID- 19 than those with TDT/NTDT (10.5 vs. 4.8 COVID/100 patients). Notably, 92% of the cases were mild, with neither age nor the specific RBCD affecting severity. The number of comorbidities, notably obesity and hypertension, that patients had prior to infection was associated with more severe COVID- 19. During the infection, the presence of vaso-occlusive crises, acute chest syndrome, kidney failure, and ground-glass opacities on chest tomography scans were associated with a more severe clinical picture. The vaccination rate (32%) mirrored that of the general population and showed a protective effect against severe COVID- 19. The observed mortality rate was 0.7%, aligning with Europe's general population.
CONCLUSION: SARS-CoV- 2 infection in SCD and TDT/NTDT patients is mild and without higher mortality than the general population. The ERN-Eurobloodnet's registry collaborative structure exemplifies the power of international cooperation in tackling rare diseases, especially during health emergencies.